Indian Journal of Physical Medicine and Rehabilitation

Register      Login

VOLUME 23 , ISSUE 2 ( June, 2012 ) > List of Articles

RESEARCH ARTICLE

Effectiveness of Tolperisone Hydrochloride with Aceclofenac as Combined Therapy in Acute Low Back Pain.

B Bhattacharjya, S Mohammad Naser, A Biswas, F Kamal, K Banerjee

Citation Information : Bhattacharjya B, Naser SM, Biswas A, Kamal F, Banerjee K. Effectiveness of Tolperisone Hydrochloride with Aceclofenac as Combined Therapy in Acute Low Back Pain.. Indian J Phy Med Rehab 2012; 23 (2):74-78.

DOI: 10.5005/ijopmr-23-2-74

Published Online: 00-06-2012

Copyright Statement:  Copyright © 2012; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Objective

An open label, non-randomised, prospective study was conducted to evaluate the effectiveness of tolperisone hydrochloride 150mg thrice daily with aceclofenac 100mg twice daily compared to aceclofenac 100mg twice daily alone for the treatment of acute low back pain (LBP) for 14 days. total (n=242) patients recruited for the study were divided into two treatment groups. One of the group (n=124) received oral tolperisone plus aceclofenac and the other (n=118) Aceclofenac alone. The pain intensity was assessed by visual analogue scale. Patients were informed to report any adverse effect encountered during the study period. The overall effect of the drug (global assessment of the study medication) on pain and adverse effects were assessed by the patients at the end of the trial on a categorical scale. There was significant reduction in pain score in the tolperisone group than aceclofenac group with insignificant adverse effects which didn't require discontinuation of the study. Tolperisone when added with aceclofenac can be more effective than aceclofenac alone for relief of acute LBP with minimum adverse effects.


PDF Share
  1. Electromyographic evidence of paraspinal muscle spasm during sleep in patients with low back pain. Clin J Pain 1985:147-54.
  2. The prevalence of disability among adults. OPCS surveys of disability in Great Britain, Report 1. London: Her Majesty's Stationery Office, 1988.
  3. Mydeton. A centrally acting muscle relaxant drug from Gedeon Richter Ltd. Acta Pharm Hung 2002; 72: 49-61.
  4. Interleukin -1â induces cytosolic phospholipase A2 and prostaglandin H synthase in rheumatoid synovial fibroblasts: evidence for their roles in the production of prostaglandin E2. Arthritis Rheum 1994;37:653-61.
  5. Aceclofenac blocks prostaglandin E2 production following its intracellular conversion into cyclooxygenase inhibitors. Eur J Pharmacol 1997; 329:181-7.
  6. Aceclofenac blocks prostaglandin E2 production following its intracellular conversion into cyclooxygenase inhibitors. Eur J Pharmacol 1997;329: 181-18.
  7. Tolperisone. A typical representative of a class of centrally acting muscle relaxants with less sedative side effects. CNS Neurosci Ther 2008;14(2): 107-19.
  8. Tolperisone: Martindale - The Complete Drug Reference. 36th ed. London: Pharmaceutical Press, 2009: 1899.
  9. Efficacy and tolerance of repeated oral doses of tolperisone hydrochloride in the treatment of painful reflex muscle spasm: results of a prospective placebocontrolled double-blind trial. Pain 1996;67:417-25.
  10. Tolperisone. J Anaesth Clin Pharmacol 2010; 26: 363-4.
  11. Reversible adrenergic alpha-receptor blocking action of 2, 4'- Dimethy l-3-piperidino- propiophenone (tolperisone). Jpn J Pharmacol 1976 Oct; 26: 543-50.
  12. Antinociceptive effects of sodium channel-blocking agents on acute pain in mice. J Pharmacol Sci 2004;95:181-8.
  13. Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage gated sodium and calcium channels. J Pharmacol Exp Ther 2005;315:1237-46.
  14. Tolperisone drug review. J Assoc Physicions India 2010; 58: 127-28.
  15. A hase IV observational multi-Centre, open-label study on efficacy and safety of tolperisone 150 mg in patients with painful muscle spasm associated with degenerative or inflammatory diseases of the musculoskeletal system. J Assoc Physicions India 2011; 59:33-37.
  16. Efficacy and safety of Tolperisone in patient with low back pain: A double blind randomised study. European Review for Medical and Pharmacological Sciences 2008;12: 229-35.
  17. Evaluation of Sedative effects of single and repeated doses of 50 mg and 150 mg Tolperisone hydrochloride: results of prospective, randomized doubleblind, placebo controlled trial. Pharmacopsychiatray 1998;31:137-42.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.