Indian Journal of Physical Medicine and Rehabilitation

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VOLUME 29 , ISSUE 2 ( 2018 ) > List of Articles

ORIGINAL ARTICLE

Guillain–Barré Syndrome: Profile of 120 Patients with respect to Response to Various Modalities of Treatment

Vishal A Chafale, Alak Pandit, Satish A Lahoti, Tajendranath Kundu, Goutam Ganguly

Keywords : Guillain–Barré syndrome, Intravenous steroid, Prognosis, Treatment.,Clinical profile

Citation Information : Chafale VA, Pandit A, Lahoti SA, Kundu T, Ganguly G. Guillain–Barré Syndrome: Profile of 120 Patients with respect to Response to Various Modalities of Treatment. Indian J Phy Med Rehab 2018; 29 (2):31-36.

DOI: 10.5005/jp-journals-10066-0022

License: CC BY-ND 3.0

Published Online: 00-06-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Introduction: Guillain–Barré Syndrome (GBS) is an inflammatory polyradiculoneuropathy with varied clinical manifestation and often dismal prognosis if not promptly treated. Recommended treatment modalities [intravenous immunoglobulin (IVIG) and plasma exchange (PE)] are costly and the role of steroids is controversial. Materials and methods: In this study, we reviewed the clinical and laboratory findings of consecutive patients with GBS (n = 120) and explored factors associated with outcome. We also compared response to different modalities of treatment including steroids. Results: There was no significant difference between the treatment outcomes of IVIG and PE and we found a nonsignificant trend toward improvement with intravenous (IV) steroid. We observed 4.17% mortality and most common cause of death was respiratory failure. Conclusion: Increasing age, delay in starting treatment, early peak disability, autonomic dysfunction, bulbar weakness, and reduced compound muscle action potential (CMAP) were associated with a poorer outcome. Group of patients treated with IVIG and plasmapheresis showed more improvement than the IV methylprednisolone group.


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