Effect of Platelet-rich Plasma Injection on Disability and Pain in Individuals with Osteoarthritis Knee: A Follow-up Study of Six Months
Mahima Agrawal, Mrinal Joshi
Platelet-rich plasma, Visual analog scale, Western Ontario McMaster osteoarthritis index score,Osteoarthritis knee
Citation Information :
Agrawal M, Joshi M. Effect of Platelet-rich Plasma Injection on Disability and Pain in Individuals with Osteoarthritis Knee: A Follow-up Study of Six Months. Indian J Phy Med Rehab 2019; 30 (2):41-45.
Objectives: To demonstrate the effect of autologous platelet-rich plasma (PRP) injections on pain and functional activities in patients with osteoarthritis (OA) knee.
Study design: Prospective interventional study.
Materials and methods: A detailed demographic data were collected, and each patient was examined clinically and radiographically. Complete blood counts, prothrombin time (PT)/international normalized ratio (INR), and X-rays of bilateral knees were taken. Radiological grading was done on Kellgren–Lawrence (KL grading) OA scale. Each individual was explained and informed consent was taken before the procedure. Three injections of PRP were given at an interval of 2 weeks. Detailed clinical examination was done at the end of 1 month and 6 months postinjection. Pain assessment was done on visual analog scale (VAS) and Western Ontario McMaster (WOMAC) OA index was used for comprehensive documentation of pain, stiffness, and overall disability experienced by the individual suffering from OA knee.
Results: The mean VAS score for pain was 6.53, 4.24, and 3.76 before treatment, 1 month posttreatment, and 6 months postinjection, respectively, in KL grades I and II individuals. On WOMAC scale, mean pain scores were 17.15, 7.90, and 7.39 before treatment, 1 month posttreatment, and 6 months postinjection, respectively. Mean stiffness scores were 5.56, 3.15, and 2.56 39 before treatment, 1 month posttreatment, and 6 months postinjection, respectively. Mean functional capacity scores were 46.49, 27.78, and 23.51 before treatment, 1 month posttreatment, and 6 months postinjection, respectively.
Conclusion: An overall reduction in pain and improvement in functional status were observed in all individuals suffering from OA knee of any grade. In the light of other studies, it can be concluded that the use of PRP injection has proven to be a promising treatment modality for OA.
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