Citation Information :
Chafale VA, Pandit A, Lahoti SA, Kundu T, Ganguly G. Guillain–Barré Syndrome: Profile of 120 Patients with respect to Response to Various Modalities of Treatment. Indian J Phy Med Rehab 2018; 29 (2):31-36.
Introduction: Guillain–Barré Syndrome (GBS) is an inflammatory polyradiculoneuropathy with varied clinical manifestation and often dismal prognosis if not promptly treated. Recommended treatment modalities [intravenous immunoglobulin (IVIG) and plasma exchange (PE)] are costly and the role of steroids is controversial.
Materials and methods: In this study, we reviewed the clinical and laboratory findings of consecutive patients with GBS (n = 120) and explored factors associated with outcome. We also compared response to different modalities of treatment including steroids.
Results: There was no significant difference between the treatment outcomes of IVIG and PE and we found a nonsignificant trend toward improvement with intravenous (IV) steroid. We observed 4.17% mortality and most common cause of death was respiratory failure.
Conclusion: Increasing age, delay in starting treatment, early peak disability, autonomic dysfunction, bulbar weakness, and reduced compound muscle action potential (CMAP) were associated with a poorer outcome. Group of patients treated with IVIG and plasmapheresis showed more improvement than the IV methylprednisolone group.
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